ZymoBIOMICS Services

Computer with graphs on screen
  • Complete Solution for Unbiased Microbiome Profiling
  • Quick Turnaround as Little as 2 Weeks
  •  Species-Level Resolution with 16S Sequencing

Focus on discoveries. We take care of everything else.


Comprehensive & User-Friendly Report

Let Us Do the Work.

Microbiome Report Computer
Microbiome Reports

Get all the data in a single, comprehensive report.


Publication-Ready Data at Your Fingertips

All ZymoBIOMICS Services include comprehensive bioinformatics and statistical analyses for each microbiomics project. The report can be customized according to each unique project or application. Let Zymo Research do the bioinformatics so that you don’t have to!

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Cited in Major Publications

Read peer-reviewed citations to discover how scientists are using these services.

Bullman et al. used the ZymoBIOMICS Targeted Sequencing Service to show that Fusobacterium and other pathogenic microbes are frequently found in both the primary and distant metastatic sites of the most aggressive and deadliest colon cancers. The authors demonstrated the potential for antibiotics to help fight Fusobacterium-positive metastatic colon cancer in a mouse model containing patient-derived xenografts.

Akyol et al. performed 16S and 18S analysis of anaerobic digestates using the ZymoBIOMICS Targeted Sequencing Service to assess microbial diversity in lignocellulose-rich digestates. The most abundant bacterial and fungal genera were consistent across digestate samples.

The authors investigated the role of the mucosal immune system, the commensal gut microbiota, and the intestinal epithelium in the loss of intestinal homeostasis that drives inflammatory bowel disease (IBD). The ZymoBIOMICS Targeted Sequencing Service was used to determine altered microbiome diversity in mice with different types of inflammation and to demonstrate that rapamycin, the drug used to inhibit mTOR signaling in mice in vivo, did not affect the commensal gut microbiota.

Improving the methane production and energy yield of biogas reactors by fungal bioaugmentation was investigated in this research. Results from testing with the ZymoBIOMICS Targeted Sequencing Service revealed that both fungal bioaugmentation and the different use of either whole crop or crop residues influenced the composition of the bacterial community in the reactors, with several taxa only identified in the bioaugmented samples, but that neither factor influence the methanogenic archaea composition, even though the methane yield in bioaugmented samples increased by 15-33%.

The authors investigated the microbial pools associated with landfill reactors that are impacted by nanomaterials. Using the ZymoBIOMICS Targeted Sequencing Service, they discovered that the bacterial communities were similar between control reactors and nanomaterial-containing reactors, but the archaea communities were highly different.

This study investigated how varying interchange ratios in wastewater treatment affects microbial community composition. Sample analysis via the ZymoBIOMICS Targeted Sequencing Service demonstrated that the relative abundance of the phyla Proteobacteria, Acidobacteria, and Bacteroidetes varied according to the interchange ratio and that the species of Thiothrix were highly abundant in all samples, revealing their potential importance to wastewater treatment processes.

This study is the first to investigate the bacterial community of the egg parasitoid Telenomus tridentatus. Using the ZymoBIOMICS Targeted Sequencing Service, Ramírez-Ahuja et al. showed the gut bacterial community of this parasitoid wasp is dominated by Proteobacteria and Actinobacteria and lay the groundwork for future studies regarding the role of bacterial communities in wasp species.


Microbiomics-Grade Technologies

Any sample. Ultra-clean. Rigorous controls.

Infinity Dna

Human samples, water, soil, food testing , pathogen surveillance

Certification Of Ultra-Clean Certified

Low Bioburden Reagents limit sample contamination.

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Zymo's mock communities deemed "Regulatory-grade genomes" by FDA


Reliable and Unmatched Sample Processing

Zymo Research was the first company to develop microbiomics solutions, from collection to conclusion, based on new rigorous standards for microbiome measurements. Zymo Research is leading the initiative to improve reproducibility and accuracy in the field by developing the first commercially available microbiome standards. The FDA has accepted the ZymoBIOMICS Microbial Community standards as Regulatory-Grade Genomes in the Database for Reference Grade Microbial Sequences (FDA-ARGOS).The standards are utilized to develop and optimize every step of the microbiomics workflow, ensuring high-quality, unbiased results.

Sampling of different samples

Unbiased Microbiome Profiling

Microbiome Standards Included in Every Project.

microbiome composition graph

All Sources of Bias Taken Into Account

Microbiome graph with unbiased and biased results
Zymo Research’s unparalleled DNA extraction protocols, commonly reported in literature, are certified to have unbiased microbial lysis and minimize bias during DNA extraction. Common DNA extraction protocols reported in literature are found to have a dramatic bias as demonstrated in the figure above.

Preserve Microbiome Samples at Ambient Temperature with DNA/RNA Shield
Microbiome Fecal Sample graph
Various sample collection devices prefilled with DNA/RNA Shield are available to help streamline your collection process.
Controlling PCR Chimera during 16S Library Preparation
Microbiome Quick 16S graph
The innovative use of real-time PCR during library preparation minimizes PCR chimera formation.

Redefining targeted sequencing

Species-Level Resolution with 16S Sequencing.

Species level Pie Chart
species level chart

Reshape the Coverage of 16S Primers

Microbiome Reshape Chart
The phylogenetic coverage of 16S sequencing is determined by the selection of general bacterial 16S primers used. As more microbes are newly discovered, the design of 16S primer sets becomes even more critical to successful coverage of sample composition. The 16S primers designed by Zymo Research significantly improve coverage of primers targeting V1-V2 and V3-V4 regions. These two regions confer higher taxonomy resolution than the V4 region.

ZymoBIOMICS Shotgun Service

Take your samples further.


Microbiome CosmosID

ZymoBIOMICS Shotgun Service

Shotgun metagenomic sequencing offers strain-level resolution, multiple-kingdom identification, and functional profiling.

In partnership with CosmosID, Zymo Research provides the most complete and sophisticated solution for shotgun metagenomics. The bioinformatics analysis for the ZymoBIOMICS Shotgun Service features:

Performance

  • Identification with industry-leading sensitivity and precision
  • Strain-level resolution of all microbial kingdoms (bacteria, archaea, viruses, protists, fungi)
Microbiome Shotgun Service

World’s largest curated and customizable databases

  • 150,000+ genomes and gene sequences
  • 100s of millions of biomarkers
  • Data structure follows the phylogenetic hierarchy of genomes, enabling accurate classification, even of unknown strains, based on this virtual tree of life

  Target Organisms Sequencing Platform Price Per Sample*
ZymoBIOMICS Targeted Sequencing Service: 16S (V1-V2, V3-V4, V4, or V6-V8) Bacteria, Archaea Illumina MiSeq ≤ $100
ZymoBIOMICS Targeted Sequencing Service: ITS Fungi Illumina MiSeq ≤ $100
ZymoBIOMICS Targeted Sequencing Service: 18S Eukaryotes Illumina MiSeq ≤ $100
ZymoBIOMICS Shotgun Metagenomic Service Bacteria, Viruses, Fungi, Protists Illumina HiSeq ≤ $300
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