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DNA Methylation Services Comparison

Genome-Wide DNA Methylation Analysis

Single Base Resolution

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Next-Gen bisulfite sequencing platforms for DNA methylation analysis

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Applicable to a broad range of sample sources (human, mouse, rat, plant, etc.) and compatible with low DNA input

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Streamlined workflows with comprehensive bioinformatic analysis and high quality publishable data delivery

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Can be customized and combined with rapid turnaround at an affordable cost

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Methyl-MiniSeq®

This platform (an improved version of Reduced Representation Bisulfite Sequencing for greater coverage) can be used to detect 3-4 million unique CpG sites, allowing >85% coverage of all CpG islands and >80% of all gene promoters for a maximal amount of methylation data from less sequencing reads, reducing the overall cost. The system is conducive to biomarker discovery by providing for the identification and analysis of differentially methylated regions (DMRs) between samples.

Methyl-MidiSeq®

MidiSeq® can be used to detect 8-9 million unique CpG sites. It extends the coverage of the Methyl-MiniSeq® platform to include genetic regulatory elements, gene bodies, and repeated DNA sequences. It is a good option for those researchers requiring methylome analysis outside of gene promoters and CpG islands.

Methyl-MaxiSeq®

The Methyl-MaxiSeq® platform (whole-genome bisulfite sequencing) is for the detection of DNA methylation across the entire genome. DNA methylation information is provided in CpG context as well as in the less common CHG and CHH contexts. The platform attains an average read coverage of 15-20X per base (for the human genome). This can be modified depending on your requirements. Since whole-genome sequence is provided, SNP analysis can be performed simultaneously.


Services are customizable and can be combined to suit your needs!


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